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Motor functioning was evaluated starting at 2 weeks post-surgery and testing was conducted on a biweekly basis using a walking track analysis where the rats were made to walk in a confined walkway lined with white paper and led into a dark shelter
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These results suggest that signaling through MOR may be desensitized through a heterologous mechanism by receptor tyrosine kinase activation and that this mechanism may have important implications for pain control following tissue injury
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